Offered listed below are fresh advances in biochemical, toxicological, and regulatory features of oxidative drug metabolizing enzymes. in most cases cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are lined. additionally, the booklet bargains with genotoxicity reviews and toxicological interactions of environmental chemical compounds and mechanisms of mutagenicity and tumor formation. the development of genetically engineered mammalian cells for the construction of a selected P450 isozyme and the appliance of those mobile traces in drug metabolism, mutagenicity and toxicity stories are defined intimately. additional, perception is supplied into how a few aquatic species deal with toxins and their genotoxicity.
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